No. You can switch your currently open design to any layout by selecting Switch to a Different Layout on the File menu. Once you select the new layout a copy of your design is created for the new layout. You will need to save this copy as if you created a new design. Keep in mind that your original design is still open and can be displayed or closed by selecting it on the Window menu. Also, if the size of the design is smaller in the new layout some objects may be re-positioned so they fit.